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A decrease in fibula growth rate has been observed in prematures given oral tetracycline in doses of 25 mg/kg every 6 hours.
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Depending on the animal, the dosage is adjusted to preferably achieve a serum concentration between about 005 and 10 μg/ml, between about 001 and 10 μg/ml, and between about 0005 and 10 μg/ml tetracycline or analog thereof.

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